Malaria is one of the oldest human parasites and still over one million deaths occur annually. We have established a fluorescence-based assay that will allow us to test the efficiency of growth inhibition for a variety of chemicals on the Plasmodium falciparum strain of the parasite in culture. Using a 384-well microtiter plate format and a DNA dye-binding assay, we show that the growth inhibitory effects of the known antimalarial drug chloroquine can rapidly and sensitively be detected. In collaboration with the Lokey lab we hope to test some of the 15,000 small compounds in our chemical libraries for their antimalarial properties. We hope to identify a compounds that inhibit growth of the parasite and pursue further testing.